Catalog Number: 4509
Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Biological Activity
Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.
Technical Data
  • M.Wt:
    317.38
  • Formula:
    C15H11NO3S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    307543-71-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
    Papandreou et al.
    Blood., 2011;117:1311
  2. InterfERing with endoplasmic reticulum stress.
    Kraskiewicz and FitzGerald
    Trends Pharmacol.Sci., 2012;33:53
Citations:

The citations listed below are publications that use Tocris products. Selected citations for STF 083010 include:

1 Citations: Showing 1 - 1

  1. Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production.
    Authors: Kim Et al.
    Cell Death Dis 2015;194:4498

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