Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Biological ActivitySTF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
Papandreou et al.
InterfERing with endoplasmic reticulum stress.
Kraskiewicz and FitzGerald
Trends Pharmacol.Sci., 2012;33:53
Citations for STF 083010
The citations listed below are publications that use Tocris products. Selected citations for STF 083010 include:
4 Citations: Showing 1 - 4
The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response.
Authors: Xu Et al.
JCI Insight 2019;4
IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats.
Authors: Chen Et al.
J Neuroinflammation 2018;15:32
Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay.
Authors: Ko Et al.
Sci Rep 2017;7:14940
Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production.
Authors: Kim Et al.
Cell Death Dis 2015;194:4498
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