Inhibitor of IRE1α
endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+
multiple myeloma (MM) cells in vitro
; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo
. Does not alter IRE1α
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All Tocris products are intended for laboratory research use only.
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
Papandreou et al.
InterfERing with endoplasmic reticulum stress.
Kraskiewicz and FitzGerald
Trends Pharmacol.Sci., 2012;33:53
The citations listed below are publications that use Tocris products. Selected citations for STF 083010 include:
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