STF 083010

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4509/10
4509/50
STF 083010 | CAS No. 307543-71-1 | IRE1 Inhibitors
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Description: Inhibits IRE1α endonuclease activity

Chemical Name: N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Technical Data

M.Wt:
317.38
Formula:
C15H11NO3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
307543-71-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
    Papandreou et al.
    Blood., 2011;117:1311
  2. InterfERing with endoplasmic reticulum stress.
    Kraskiewicz and FitzGerald
    Trends Pharmacol.Sci., 2012;33:53

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Citations for STF 083010

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