STK16-IN-1

Key Product Details

Product Description

STK16-IN-1 is a serine/threonine protein kinase 16 (STK16) inhibitor (IC₅₀ = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC₅₀ values are 856 and 867 nM, respectively) and mTOR kinase (IC₅₀= 5.56 μM).

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Product Specifications for STK16-IN-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for STK16-IN-1

The following data is based on the product molecular weight 293.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.41 mL	17.05 mL	34.09 mL
5 mM	0.68 mL	3.41 mL	6.82 mL
10 mM	0.34 mL	1.70 mL	3.41 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liu Discovery of a highly selective STK16 kinase inhibitor ACS.Chem.Biol. 2016 PMID: 27082499

Product Documents for STK16-IN-1