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STK16-IN-1

Catalog #: 6036 Datasheet / COA / SDS

Discontinued Product

6036 has been discontinued.
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STK16-IN-1 | CAS No. 1223001-53-3 | Other Kinase Inhibitors
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Description: Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases

Chemical Name: 1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

STK16-IN-1 is a serine/threonine protein kinase 16 (STK16) inhibitor (IC50 = 295 nM). Reduces cell number and increases accumulation of binucleated MCF-1 cells. Enhances cell apoptosis in combination with chemotherapeutics. Also inhibits PI 3-Kδ and PI-3-Kγ kinases (IC50 values are 856 and 867 nM, respectively) and mTOR kinase (IC50= 5.56 μM).

Technical Data

M.Wt:
293.3
Formula:
C17H12FN3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1223001-53-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.

Background References

  1. Discovery of a highly selective STK16 kinase inhibitor
    Liu et al.
    ACS.Chem.Biol., 2016;11:1537

Product Datasheets

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