SU 6656 New
Chemical Name: 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Biological ActivityPotent ATP-competitive Src family kinase inhibitor (IC50 values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC50 = 0.22 μM for the α2 kinase domain). Cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sorafenib.
Ross et al.
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling.
Blake et al.
Mol.Cell Biol., 2000;20:9018
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