SU 6668

Catalog # Availability Size / Price Qty
3335/10
3335/50
SU 6668 | CAS No. 252916-29-3 | PDGF Receptor Inhibitors
1 Image
Description: PDGFR, VEGFR and FGFR inhibitor
Alternative Names: TSU68, Orantinib

Chemical Name: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

Technical Data

M.Wt:
310.35
Formula:
C18H18N2O3
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
252916-29-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for SU 6668

The citations listed below are publications that use Tocris products. Selected citations for SU 6668 include:

2 Citations: Showing 1 - 2

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SU 6668

There are currently no reviews for this product. Be the first to review SU 6668 and earn rewards!

Have you used SU 6668?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.