Catalog Number: 4943
Chemical Name: N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[(3',6'-diazido-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]glycine (acetyloxy)methyl ester
Biological Activity
Reported to be a hydrogen sulphide (H2S) fluorescent probe. Contains an acetoxymethyl ester, which enhances cell permeability and is hydrolyzed inside the cell to trap the probe. Used to visualize VEGF-induced H2S production in human umbilical vein endothelial cells (HUVECS). Excitation wavelength ~ 495 nm; emission maximum ~ 520 nm.
Technical Data
  • M.Wt:
    685.55
  • Formula:
    C31H23N7O12
  • Solubility:
    Soluble to 20 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    1416872-50-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the Regents of the University of California
Background References
  1. Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production.
    Lin et al.
    Proc.Natl.Acad.Sci.USA., 2013;110:7131
  2. Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.
    Lippert et al.
    J.Am.Chem.Soc., 2011;133:10078

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