Catalog Number: 3586
Alternate Names: GR 43175
Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Biological Activity
5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites.
    Peroutka and McCarthy
    Eur.J.Pharmacol., 1989;163:133
  2. Sumatriptan in acute migraine: pharmacology and review of world experience.
    Headache, 1990;30:554
  3. Effect of sumatriptan in different models of pain in rats.
    Ottani et al.
    Eur.J.Pharmacol., 2004;497:181
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