Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
Biological Activity5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites.
Peroutka and McCarthy
Sumatriptan in acute migraine: pharmacology and review of world experience.
Effect of sumatr. in different models of pain in rats.
Ottani et al.
Citation for Sumatriptan succinate
The citations listed below are publications that use Tocris products. Selected citations for Sumatriptan succinate include:
1 Citation: Showing 1 - 1
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
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sumatriptan (1 μΜ)