Non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50
= 21 μ
M). Causes a significant reduction in serum calcium concentrations in vivo
following i.p. administration.
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Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin.
Katayama et al.