SYM 2081

Key Product Details

Product Description

SYM 2081 is a potent and highly selective kainate receptor agonist, with an IC₅₀ for inhibition of [³H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations.

Licensing Information

Sold with the permission of Annovis Inc.

Product Specifications for SYM 2081

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SYM 2081

The following data is based on the product molecular weight 161.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	12.41 mL	62.05 mL	124.10 mL
2.5 mM	2.48 mL	12.41 mL	24.82 mL
5 mM	1.24 mL	6.21 mL	12.41 mL
25 mM	0.25 mL	1.24 mL	2.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Zhou (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 8996224
• Jones Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 1997 PMID: 9225313
• Savidge Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 1999 PMID: 10219975
• Donevan The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 1998 PMID: 9580595

Product Documents for SYM 2081