TAC

Key Product Details

Product Description

TAC is a telomerase reverse transcriptase (TERT) activator. TAC upregulates TERT gene transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC enhances telomere synthesis, reduces tissue aging markers, cellular senescence, and inflammatory cytokines. In the brain, TAC induces neurogenesis, reduces neuroinflammation, and preserves cognitive function.

Product Specifications for TAC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TAC

The following data is based on the product molecular weight 331.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Shim TERT activation targets DNA methylation and multiple aging hallmarks. Cell 2024 PMID: 38908367

Product Documents for TAC