TAK 779

Key Product Details

Product Description

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC₅₀ values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC₅₀ = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Product Specifications for TAK 779

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TAK 779

The following data is based on the product molecular weight 531.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.83 mL	94.14 mL	188.28 mL
0.5 mM	3.77 mL	18.83 mL	37.66 mL
1 mM	1.88 mL	9.41 mL	18.83 mL
5 mM	0.38 mL	1.88 mL	3.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Suzaki A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur.Respir.J. 2008 PMID: 18094012
• Takami TAK-779, a nonpeptide CC chemokine receptor antagonist, protects the brain against focal cerebral ischemia in mice. J.Cereb.Blood Flow Metab. 2002 PMID: 12142563
• Baba A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc.Natl.Acad.Sci.U.S.A. 1999 PMID: 10318947

Product Documents for TAK 779