Talabostat mesylate

Key Product Details

Product Description

Talabostat mesylate is a potent DPP IV inhibitor (IC₅₀ values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

Product Specifications for Talabostat mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Talabostat mesylate

The following data is based on the product molecular weight 310.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.12 mL	32.24 mL
5 mM	0.64 mL	3.22 mL	6.45 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Okondo Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol. 2018 PMID: 29396289
• Okondo DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat.Chem.Biol. 2017 PMID: 27820798

Product Documents for Talabostat mesylate