Talabostat mesylate

Catalog # Availability Size / Price Qty
Talabostat mesylate | CAS No. 150080-09-4 | Inflammasomes Activators
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Description: Potent DPP IV inhibitor; activates NLRP1b inflammasome
Alternative Names: Val-boroPro, BXCL 701

Chemical Name: B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

Talabostat mesylate is a potent DPP IV inhibitor (IC50 values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
    Okondo MC, Johnson DC, Sridharan R et al.
    Nat. Chem. Biol.
  2. Inhibition of Dpp8/9 activates the Nlrp1b inflammasome.
    Okondo et al.
    Cell Chem.Biol., 2018;25:262

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Citation for Talabostat mesylate

The citations listed below are publications that use Tocris products. Selected citations for Talabostat mesylate include:

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