Talopram hydrochloride

Discontinued Product

3145 has been discontinued.
View all Adrenergic Transporter Inhibitors products.
Talopram hydrochloride | CAS No. 7013-41-4 | Adrenergic Transporter Inhibitors
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Description: Potent, selective inhibitor of noradrenalin transporters
Alternative Names: Lu 3-010

Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine hydrochloride

Purity: ≥99%

Product Details

Biological Activity

Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram.
    Schou et al.
    Mol.Imaging Biol., 2006;8:1
  2. 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of DA, NE, and serotonin uptake.
    Bogeso et al.
    J.Med.Chem., 1985;28:1817
  3. From the selective serotonin transporter inhibitor cital. to the selective NE transporter inhibitor talopram: synthesis and structure-activity relationship studies.
    Eildal et al.
    J.Med.Chem., 2008;51:3045

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