Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine hydrochloride
Biological ActivityTalopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram.
Schou et al.
Mol.Imaging Biol., 2006;8:1
3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of DA, NE, and serotonin uptake.
Bogeso et al.
From the selective serotonin transporter inhibitor cital. to the selective NE transporter inhibitor talopram: synthesis and structure-activity relationship studies.
Eildal et al.
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