Talsupram hydrochloride

Catalog # Availability Size / Price Qty
4352/10
4352/50
Cat.No. 4352 - Talsupram hydrochloride | C20H25NS.HCl | CAS No. 25487-28-9
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Description: Selective inhibitor of noradrenalin transporters

Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride

Purity: ≥98%

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Biological Activity

Selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.

Technical Data

M.Wt:
347.95
Formula:
C20H25NS.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
25487-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter.
    McConathy et al.
    Nucl.Med.Biol., 2004;31:705
  2. Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors.
    Rowlett et al.
    J.Pharmacol.Exp.Ther., 2004;310:342
  3. Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram.
    Schou et al.
    Mol.Imaging Biol., 2006;8:1

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