Talsupram hydrochloride

Catalog # Availability Size / Price Qty
Talsupram hydrochloride | CAS No. 25487-28-9 | Adrenergic Transporter Inhibitors
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Description: Selective inhibitor of noradrenalin transporters

Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride

Purity: ≥98%

Product Details
Supplemental Products

Biological Activity

Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.

Technical Data

Soluble to 20 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter.
    McConathy et al.
    Nucl.Med.Biol., 2004;31:705
  2. Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram.
    Schou et al.
    Mol.Imaging Biol., 2006;8:1
  3. Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors.
    Rowlett et al.
    J.Pharmacol.Exp.Ther., 2004;310:342

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