Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus
oocyte extracts (IC50
= 12 μ
M) and blocks cyclin degradation in interphase extract.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
Zeng et al.
Cancer Cell., 2010;18:382
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination.
Zeng & King
The citations listed below are publications that use Tocris products. Selected citations for TAME hydrochloride include:
Showing Results 1 - 1 of 1