Catalog Number: 4506
Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride
Biological Activity
Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.
Technical Data
  • M.Wt:
    378.87
  • Formula:
    C14H22N4O4S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    1784-03-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
    Zeng et al.
    Cancer Cell., 2010;18:382
  2. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination.
    Zeng & King
    Nat.Chem.Biol., 2012;8:383
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TAME hydrochloride include:

1 Citations: Showing 1 - 1

  1. KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
    Authors: Coles Et al.
    PLoS Genet 2015;11:e1005525

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