Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride
Biological ActivityTAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
Zeng et al.
Cancer Cell., 2010;18:382
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination.
Zeng & King
Citation for TAME hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for TAME hydrochloride include:
1 Citation: Showing 1 - 1
KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
Authors: Coles Et al.
PLoS Genet 2015;11:e1005525
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