Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Biological Activity5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites.
Hamik et al.
Effects of tandospirone in three behavioral tests for anxiolytics.
Pollard et al.
Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions.
Matsubara et al.
Brain Res., 2006;1112:126
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