Catalog Number: 2854
Alternate Names: SM-3997
Chemical Name: (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Biological Activity
5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
Technical Data
  • M.Wt:
    419.95
  • Formula:
    C21H29N5O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    99095-10-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.
    Matsubara et al.
    Brain Res., 2006;1112:126
  2. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites.
    Hamik et al.
    Biol.Psychiatry, 1990;28:99
  3. Effects of tandospirone in three behavioral tests for anxiolytics.
    Pollard et al.
    Eur.J.Pharmacol., 1992;221:297

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