Tandospirone hydrochloride

Tocris Bioscience | Catalog # 2854

Selective 5-HT1A partial agonist
Tocris Bioscience

Key Product Details

Description

Selective 5-HT1A partial agonist

Alternative Names

SM-3997
View all 5-HT1 Receptor Agonists »

Product Description

Tandospirone hydrochloride is a 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Product Specifications for Tandospirone hydrochloride

Molecular Weight

419.95

Formula

C21H29N5O2.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride

CAS Number

99095-10-0

PubChem ID

13422623

InChI Key

ACVFJYKNBOHIMH-DPFKZJTMSA-N

SMILES

[H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 41.99 100
DMSO 41.99 100

Preparing Stock Solutions for Tandospirone hydrochloride

The following data is based on the product molecular weight 419.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.91 mL 23.81 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Tandospirone hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tandospirone hydrochloride

For research use only

Citations for Tandospirone hydrochloride

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