Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide
Biological ActivityTAPI 1 is a TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.
This product is typically reconstituted in DMSO.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy.
Sommer et al.
Neurosci. Lett., 1997;237:45
Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing.
Mohler et al.
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