Chemical Name: N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide
Biological ActivityInhibits formation of miR-210 by binding to pre-miR-210 Dicer binding site (Kd ~ 200 nM). Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit.
Costales et al.
Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.
Childs-Disney et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Targapremir 210
There are currently no reviews for this product. Be the first to review Targapremir 210 and earn rewards!
Have you used Targapremir 210?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image