Targapremir 210

Key Product Details

Product Description

Targapremir 210 inhibits formation of mature miR-210 (IC₅₀ = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (K_d = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.

Product Specifications for Targapremir 210

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Targapremir 210

The following data is based on the product molecular weight 592.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.69 mL	8.44 mL	16.87 mL
5 mM	0.34 mL	1.69 mL	3.37 mL
10 mM	0.17 mL	0.84 mL	1.69 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Childs-Disney Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS.Chem.Biol 2012 PMID: 22332923
• Costales Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. J.Am.Chem.Soc. 2017 PMID: 28240549

Product Documents for Targapremir 210