Targapremir 210

Catalog # Availability Size / Price Qty
6586/5
Targapremir 210 | CAS No. 1049722-30-6 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Inhibits formation of miR-210

Chemical Name: N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide

Product Details
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Biological Activity

Inhibits formation of miR-210 by binding to pre-miR-210 Dicer binding site (Kd ~ 200 nM). Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.

Technical Data

Formula:
C32H36N10O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1049722-30-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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