TASP 0390325

Tocris Bioscience | Catalog # 5729

Potent and selective V1B receptor antagonist; orally bioavailable
Tocris Bioscience

Key Product Details

Description

Potent and selective V1B receptor antagonist; orally bioavailable
View all Vasopressin Receptor Antagonists »

Product Description

TASP 0390325 is a potent and selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor). Exhibits no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. Increases ACTH levels in rats. Orally bioavailable. Antidepressant and anxiolytic.

Product Specifications for TASP 0390325

Molecular Weight

554.44

Formula

C25H29ClFN5O4.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride

CAS Number

1642187-96-9

PubChem ID

86765292

InChI Key

NUIXGNLBPARAII-UHFFFAOYSA-N

SMILES

O=C(NC(C)C)CN1C(C2=CC(OCCCN3CCOCC3)=CN=C2N=C1C4=CC=C(F)C(Cl)=C4)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 55.44 100
DMSO 55.44 100

Preparing Stock Solutions for TASP 0390325

The following data is based on the product molecular weight 554.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.80 mL 9.02 mL 18.04 mL
5 mM 0.36 mL 1.80 mL 3.61 mL
10 mM 0.18 mL 0.90 mL 1.80 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for TASP 0390325

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TASP 0390325

For research use only

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