TASP 0390325

Catalog # Availability Size / Price Qty
5729/10
5729/50
TASP 0390325 | CAS No. 1642187-96-9 | Vasopressin Receptor Antagonists
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Description: Potent and selective V1B receptor antagonist; orally bioavailable

Chemical Name: 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride

Product Details
Citations (1)
Reviews

Biological Activity

Potent and selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor). Exhibits no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. Increases ACTH levels in rats. Orally bioavailable. Antidepressant and anxiolytic.

Technical Data

Formula:
C25H29ClFN5O4.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1642187-96-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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