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TAT 14

4811 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4811/1
Cat.No. 4811 - TAT 14 | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln | CAS No. 1362661-34-4
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Description: Nrf2 pathway activator; blocks Nrf2/Keap1 interaction
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Biological Activity

Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.

Technical Data

M.Wt:
3173.6
Formula:
C137H230N48O39
Sequence:
YGRKKRRQRRRLQLDEETGEFLPIQ
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1362661-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction.
    Steel et al.
    ACS Med.Chem.Lett., 2012;3:407

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