Biological ActivityNrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction.
Steel et al.
ACS Med.Chem.Lett., 2012;3:407
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