Biological ActivityTAT 14 is a Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction.
Steel et al.
ACS Med.Chem.Lett., 2012;3:407
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