TAT-cyclo-CLLFVY

   
Product Datasheet
Catalog Number:5582
Chemical Name:
Product Details
Reviews
Biological Activity
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
Technical Data
  • M.Wt:
    2559.1
  • Formula:
    C111H188N42O24S2
  • Sequence:
    CLLFVY CGRKKRRQRRRPPQ*

    (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    1446322-66-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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