Taxol Janelia Fluor® 646
Chemical Name: 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-4-(((2S)-1-(((2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-diacetoxy-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-4-yl)oxy)-1-oxopropan-2-yl)carbamoyl)benzoate
Biological ActivityRed fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Fluorogenic: fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Protocol available. Excitation maximum = 646 nm; emission maximum = 664 nm.
Application of Taxol Janelia Fluor® 646 dye on COS7 cells
Application of Taxol Janelia Fluor® 646, dye on COS7 cells; COS7 cells were labeled with 3 µM Taxol Janelia Fluor® 646 for one hour at 37�C. Images were taken on a Leica TCS SP8 Confocal Laser Scanning Microscope.
All images kindly provided by Prof. Christian Soeller, University of Exeter; acquired by Evelina Lucinskaite, Anna Meletiou and Alexander Clowsley.
Optical Data for Taxol Janelia Fluor® 646
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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