TBK1 control PROTAC® 4

Tocris Bioscience | Catalog # 7260

Negative control for TBK1 PROTAC® 3i (Cat. No. 7259)
Tocris Bioscience

Key Product Details

Description

Negative control for TBK1 PROTAC® 3i (Cat. No. 7259)
View all Active Degrader Negative Controls »

Product Description

TBK1 control PROTAC® 4 is a negative control for TBK1 PROTAC® 3i (Cat. No. 7259). Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for TBK1 control PROTAC® 4

Molecular Weight

1093.19

Formula

C53H74BrN9O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4S)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2052306-31-5

PubChem ID

145969727

InChI Key

QMGHHBHPDDAGGO-JTTRWUFTSA-N

SMILES

CN(C(C1CCC1)=O)CCCNC2=NC(NC3=CC=C(C=C3)OCCCOCCCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](C[C@H]4C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)O)=O)=O)=NC=C2Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 109.32 100

Preparing Stock Solutions for TBK1 control PROTAC® 4

The following data is based on the product molecular weight 1093.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.57 mL 9.15 mL
5 mM 0.18 mL 0.91 mL 1.83 mL
10 mM 0.09 mL 0.46 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for TBK1 control PROTAC® 4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TBK1 control PROTAC® 4

For research use only

Citations for TBK1 control PROTAC® 4

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