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TC-A 2317 hydrochloride

Catalog #: 4066
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4066/10
4066/50
TC-A 2317 hydrochloride | CAS No. 1245907-03-2 | Aurora Kinase Inhibitors
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Description: Potent, selective Aurora kinase A inhibitor

Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data

M.Wt:
392.93
Formula:
C19H28N6O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1245907-03-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors.
    Ando et al.
    Bioorg.Med.Chem.Lett., 2010;20:4709

Product Datasheets

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Citations for TC-A 2317 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for TC-A 2317 hydrochloride include:

2 Citations: Showing 1 - 2

  1. EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions.
    Authors: Wang Et al.
    Cell Stem Cell  2019;24:419
  2. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.
    Authors: Min Et al.
    Oncotarget  2016;7:84718

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