TC ASK 10

Catalog # Availability Size / Price Qty
4825/10
4825/50
Cat.No. 4825 - TC ASK 10 | C21H21N5O.2HCl | CAS No. 1005775-56-3
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Description: Potent and selective ASK1 inhibitor; orally bioavailable

Chemical Name: 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC50 values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

Technical Data

M.Wt:
432.35
Formula:
C21H21N5O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1005775-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
    Terao et al.
    Bioorg.Med.Chem.Lett., 2012;22:7326

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