Potent ASK1 inhibitor (IC50
= 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50
= 0.51 μ
M), MEKK1, TAK1, IKKβ
, ERK1, JNK1, p38α
and B-raf (IC50
values are > 10 μ
M). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Terao et al.