Potent, high affinity CB1
receptor inverse agonist (EC50
= 11 nM in cAMP assay; Ki
= 4 nM). Demonstrates high efficacy in a hypothermia assay (ID50
= 5 mg/kg) in vivo
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Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.
Alig et al.