Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Biological ActivityTC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Acyl derivatives of p-aminosulfonamides and dap. as new inhibitors of the arginine methyltransferase hPRMT1.
Bissinger et al.
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