Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Biological ActivitySelective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.
Bissinger et al.
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