Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50
= 1.5 μ
M); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
Soluble to 50 mM in DMSO
Store at +4°C
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Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.
Bissinger et al.