TC-E 5003
Discontinued Product
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Purity: ≥98%
Biological Activity
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Acyl derivatives of p-aminosulfonamides and dap. as new inhibitors of the arginine methyltransferase hPRMT1.
Bissinger et al.
Bioorg.Med.Chem., 2011;19:3717
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Citation for TC-E 5003
The citations listed below are publications that use Tocris products. Selected citations for TC-E 5003 include:
1 Citation: Showing 1 - 1
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TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes.
Authors: Min-Jung Et al.
FEBS Lett 2020;594:2923-2930
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