Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
Biological ActivityTC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
Dufton et al.
Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.
Bürli et al.
Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library.
Forsman et al.
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