Catalog Number: 4624
Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
Biological Activity
Potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.
Technical Data
  • M.Wt:
    384.86
  • Formula:
    C20H21ClN4O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    903895-98-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.
    Bürli et al.
    Bioorg.Med.Chem.Lett., 2006;16:3713
  2. Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
    Dufton et al.
    J.Immunol., 2010;184:2611
  3. Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library.
    Forsman et al.
    Biochem.Pharmacol., 2011;81:402

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