Chemical Name: (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
Biological ActivityTC-G 1005 is a potent and selective GPBA agonist (EC50 values are 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor). TC-G 1005 increases plasma GLP-1 levels and reduces blood glucose in mice. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Citation for TC-G 1005
The citations listed below are publications that use Tocris products. Selected citations for TC-G 1005 include:
1 Citation: Showing 1 - 1
Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents.
Authors: Urso Et al.
Am.J.Physiol.Lung Cell.Mol.Physiol. 2020;318:L264
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