TC-G 1005

Catalog # Availability Size / Price Qty
5129/10
5129/50
TC-G 1005 | CAS No. 1415407-60-1 | GPBA Receptor Agonists
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Description: Potent and selective GPBA receptor (TGR5) agonist

Chemical Name: (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

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Biological Activity

Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.

Technical Data

Formula:
C25H25N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1415407-60-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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