TC-G 1005

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5129/10
5129/50

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TC-G 1005 | CAS No. 1415407-60-1 | GPBA Receptor Agonists
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Description: Potent and selective GPBA receptor (TGR5) agonist

Chemical Name: (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

TC-G 1005 is a potent and selective GPBA agonist (EC50 values are 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor). TC-G 1005 increases plasma GLP-1 levels and reduces blood glucose in mice. Orally bioavailable.

Technical Data

M.Wt:
399.48
Formula:
C25H25N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1415407-60-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for TC-G 1005

The citations listed below are publications that use Tocris products. Selected citations for TC-G 1005 include:

1 Citation: Showing 1 - 1

  1. Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents.
    Authors: Urso Et al.
    Am.J.Physiol.Lung Cell.Mol.Physiol.  2020;318:L264

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