TC-G 24

Key Product Details

Product Description

TC-G 24 is a potent GSK-3β inhibitor (IC₅₀ = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Product Specifications for TC-G 24

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC-G 24

The following data is based on the product molecular weight 330.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.24 mL	151.18 mL	302.36 mL
0.5 mM	6.05 mL	30.24 mL	60.47 mL
1 mM	3.02 mL	15.12 mL	30.24 mL
5 mM	0.60 mL	3.02 mL	6.05 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Khanfar Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 2010 PMID: 21082766

Product Documents for TC-G 24