Catalog Number: 4353
Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
Biological Activity
Potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.
    Khanfar et al.
    J.Med.Chem., 2010;53:8534
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