TC-I 15

Catalog # Availability Size / Price Qty
4527/10
4527/50
Integrin Receptor Inhibitors Small Molecule
1 Image
Description: Potent α2β1 inhibitor; displays antithrombotic activity in vivo

Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice.

Technical Data

M.Wt:
520.62
Formula:
C23H28N4O6S2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in 1.1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
916734-43-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Pennsylvania.

Product Datasheets

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Citations for TC-I 15

The citations listed below are publications that use Tocris products. Selected citations for TC-I 15 include:

2 Citations: Showing 1 - 2

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