Catalog Number: 4527
Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Biological Activity
Potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in 1.1eq. NaOH
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the University of Pennsylvania.
Background References
  1. Inhibition of integrin α2β1 ameliorates glomerular injury.
    Borza et al.
    J.Am.Soc.Nephrol., 2012;23:1027
  2. Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism.
    Miller et al.
    Proc.Natl.Acad.Sci.U.S.A., 2009;106:719
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