integrin inhibitor (IC50
values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1
at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo
; prevents ferric chloride-induced clot formation in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from the University of Pennsylvania.
Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza et al.
Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism.
Miller et al.