Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Biological ActivityTC-I 15 is a potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo; prevents ferric chloride-induced clot formation in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza et al.
Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism.
Miller et al.
Citations for TC-I 15
The citations listed below are publications that use Tocris products. Selected citations for TC-I 15 include:
2 Citations: Showing 1 - 2
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses.
Authors: Li Et al.
Nat Commun 2018;9:3600
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
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