Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Biological ActivityTC-I 15 is a potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza et al.
Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism.
Miller et al.
Citations for TC-I 15
The citations listed below are publications that use Tocris products. Selected citations for TC-I 15 include:
3 Citations: Showing 1 - 3
Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin.
Authors: Hunter Et al.
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses.
Authors: Li Et al.
Nat Commun 2018;9:3600
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
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