TC-I 15

Key Product Details

Product Description

TC-I 15 is a potent α₂β₁ integrin inhibitor (IC₅₀ values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α₂β₁ over α_vβ₃, α₅β₁, α₆β₁ and α_IIbβ₃ at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

Licensing Information

Sold under license from the University of Pennsylvania.

Product Specifications for TC-I 15

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC-I 15

The following data is based on the product molecular weight 520.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.92 mL	9.60 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL
10 mM	0.19 mL	0.96 mL	1.92 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Miller Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19141632
• Borza Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 2012 PMID: 22440900

Product Documents for TC-I 15