TC Mps1 12
Chemical Name: 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
Biological ActivityPotent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
Kusakabe et al.
ACS Med.Chem.Lett., 2012;3:560
Citation for TC Mps1 12
The citations listed below are publications that use Tocris products. Selected citations for TC Mps1 12 include:
1 Citation: Showing 1 - 1
TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.
Authors: Choi Et al.
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