TC OT 39

Catalog # Availability Size / Price Qty
4625/10
TC OT 39 | CAS No. 479232-57-0 | Oxytocin Receptor Agonists
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Description: Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist

Chemical Name: (2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide

Purity: ≥97%

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Biological Activity

TC OT 39 is a potent non-peptide oxytocin receptor partial agonist (EC50 values are 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor respectively). Also a V1a vasopressin receptor antagonist (Ki = 330 nM). Active in vivo in a rat model of uterine response.

Technical Data

M.Wt:
600.78
Formula:
C32H40N8O2S
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
479232-57-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxyt. receptor agonist.
    Frantz et al.
    J.Med.Chem., 2010;53:1546
  2. Non-peptide oxyt. agonists.
    Pitt et al.
    Bioorg.Med.Chem.Lett., 2004;14:4585

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