TC-S 7004

Key Product Details

Product Description

TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC₅₀ values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G₀ under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.

Product Specifications for TC-S 7004

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC-S 7004

The following data is based on the product molecular weight 498.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.07 mL	100.34 mL	200.67 mL
0.5 mM	4.01 mL	20.07 mL	40.13 mL
1 mM	2.01 mL	10.03 mL	20.07 mL
5 mM	0.40 mL	2.01 mL	4.01 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Anderson Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett. 2013 PMID: 24239188
• Ewton Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol.Cancer Ther. 2011 PMID: 21878655

Product Documents for TC-S 7004