Chemical Name: N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Biological ActivityTC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.
Ewton et al.
Mol.Cancer Ther., 2011;10:2104
Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Anderson et al.
Citation for TC-S 7004
The citations listed below are publications that use Tocris products. Selected citations for TC-S 7004 include:
1 Citation: Showing 1 - 1
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Authors: Blake Et al.
Sci Signal 2019;12
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