Potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50
= 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50
values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.
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All Tocris products are intended for laboratory research use only.
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
Hanan et al.