TC-S 7005

Key Product Details

Product Description

TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC₅₀ = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC₅₀ values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.

Product Specifications for TC-S 7005

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC-S 7005

The following data is based on the product molecular weight 359.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.91 mL	27.83 mL
5 mM	0.56 mL	2.78 mL	5.57 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Hanan Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg.Med.Chem.Lett. 2008 PMID: 18790636

Product Documents for TC-S 7005