TC SL C5

Catalog # Availability Size / Price Qty
6884/50
6884/10
DNA Methyltransferase Inhibitors Small Molecule
1 Image
Description: Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor

Chemical Name: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine

Purity: ≥98%

Product Details
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Biological Activity

Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (KD = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.

Technical Data

M.Wt:
323.4
Formula:
C19H21N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
827327-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1.
    Abulwerdi et al.
    ACS Chem.Biol., 2019;14:223

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