TC SL C5
Chemical Name: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine
Biological ActivityMetastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (KD = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1.
Abulwerdi et al.
ACS Chem.Biol., 2019;14:223
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