Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50
= 0.6 μ
M). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.
Soluble to 50 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Liu et al.
Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.
de Juan-Sanz et al.
PLoS ONE, 2013;8:e58863