Catalog Number: 5179
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Biological Activity
Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.
Technical Data
  • M.Wt:
    283.92
  • Formula:
    C9H2Cl4O2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    30675-13-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
    Liu et al.
    Chem.Biol., 2003;10:837
  2. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.
    de Juan-Sanz et al.
    PLoS ONE, 2013;8:e58863

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