TCN 201

Catalog # Availability Size / Price Qty
4154/10
4154/50
NMDA Receptor Antagonists Small Molecule
1 Image
Description: GluN1/GluN2A-selective NMDA antagonist

Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC50 values are 6.8 and <4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formally NR1/NR2B) FLIPR/Ca2+ assays).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
461.89
Formula:
C21H17ClFN3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
852918-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for TCN 201

The citations listed below are publications that use Tocris products. Selected citations for TCN 201 include:

11 Citations: Showing 1 - 10

  1. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
    Authors: Lassus Et al.
    Sci Rep  2018;8:17461
  2. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
    Authors: Brancaccio Et al.
    Neuron  2017;93:1420
  3. β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
    Authors: Chen Et al.
    Nature Communications  2016;7:12531
  4. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports  2016;6:36684
  5. NR2A contributes to genesis and propagation of cortical spreading depression in rats.
    Authors: Bu Et al.
    Sci Rep  2016;6:23576
  6. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
    Authors: McQuail Et al.
    J Neurosci  2016;36:12537
  7. The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood.
    Authors: Liu Et al.
    Mol Brain  2015;8:49
  8. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
    Authors: Gu Et al.
    Nat Commun  2015;6:6789
  9. Sensitivity of N-MthD.-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
    Authors: Izumi and Zorumski
    PeerJ  2015;352:267
  10. miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1.
    Authors: Hu Et al.
    J Pharmacol Exp Ther  2015;208:949
  11. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TCN 201

There are currently no reviews for this product. Be the first to review TCN 201 and earn rewards!

Have you used TCN 201?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.