TCN 201

Catalog # Availability Size / Price Qty
TCN 201 | CAS No. 852918-02-6 | NMDA Receptor Antagonists
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Description: GluN1/GluN2A-selective NMDA antagonist

Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products

Biological Activity

TCN 201 is a NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC50 values are 6.8 and <4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formally NR1/NR2B) FLIPR/Ca2+ assays).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCN 201

The citations listed below are publications that use Tocris products. Selected citations for TCN 201 include:

11 Citations: Showing 1 - 10

  1. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
    Authors: Lassus Et al.
    Sci Rep  2018;8:17461
  2. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
    Authors: Brancaccio Et al.
    Neuron  2017;93:1420
  3. β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.
    Authors: Chen Et al.
    Nature Communications  2016;7:12531
  4. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports  2016;6:36684
  5. NR2A contributes to genesis and propagation of cortical spreading depression in rats.
    Authors: Bu Et al.
    Sci Rep  2016;6:23576
  6. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
    Authors: McQuail Et al.
    J Neurosci  2016;36:12537
  7. The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood.
    Authors: Liu Et al.
    Mol Brain  2015;8:49
  8. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
    Authors: Gu Et al.
    Nat Commun  2015;6:6789
  9. Sensitivity of N-MthD.-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
    Authors: Izumi and Zorumski
    PeerJ  2015;352:267
  10. miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1.
    Authors: Hu Et al.
    J Pharmacol Exp Ther  2015;208:949
  11. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627


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