Catalog Number: 4154
Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Biological Activity
NMDA receptor antagonist selective for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 values are 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+ assays).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.
    Shin et al.
    Br.J.Pharmacol., 2011;166:1002
  2. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
    Bettini et al.
    J.Pharm.Exp.Ther., 2010;335:644
  3. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
    Edman et al.
    Neuropharmacology, 2012;63:441
  4. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
    Hansen et al.
    J.Neurosci., 2012;32:6197
  5. Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
    Gipson et al.
    Proc.Natl.Acad.Sci.U S A [Epub ahead of print], 2013;
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