Highly potent NR2B-selective NMDA receptor antagonist (Ki
= 0.8 nM); blocks NR2B-mediated calcium influx in Ltk cells (Ki
= 9.7 nM). Selective for NR2B subunit over α1
-adrenergic receptors and hERG channels (IC50
values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.
McCauley et al.