TCN 237 dihydrochloride
Chemical Name: 2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol dihydrochloride
Biological ActivityHighly potent GluN2B (formally NR2B) selective NMDA receptor antagonist (Ki = 0.8 nM); blocks GluN2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM). Selective for GluN2B subunit over α1-adrenergic receptors and hERG channels (IC50 values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
NR2B-selective N-MthD.-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.
McCauley et al.
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