TCN 237 dihydrochloride

Key Product Details

Product Description

TCN 237 dihydrochloride is a highly potent GluN2B (formally NR2B) selective NMDA receptor antagonist (K_i = 0.8 nM); blocks GluN2B-mediated calcium influx in Ltk cells (K_i = 9.7 nM). Selective for GluN2B subunit over α₁-adrenergic receptors and hERG channels (IC₅₀ values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for TCN 237 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCN 237 dihydrochloride

The following data is based on the product molecular weight 412.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.25 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• McCauley NR2B-selective N-MthD.-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J.Med.Chem. 2004 PMID: 15056006

Product Documents for TCN 237 dihydrochloride