Chemical Name: 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
Biological ActivityAgonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.
Ledda-Columbano et al.
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.
Poland et al.
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR.
Tzameli et al.
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