Chemical Name: 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
Biological ActivityAgonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway.
Ledda-Columbano et al.
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.
Poland et al.
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR.
Tzameli et al.
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