TCPOBOP

Key Product Details

Product Description

TCPOBOP is an agonist of the constitutive androstane receptor (CAR) (EC₅₀ = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.

Product Specifications for TCPOBOP

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCPOBOP

The following data is based on the product molecular weight 402.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.87 mL	124.36 mL	248.72 mL
0.5 mM	4.97 mL	24.87 mL	49.74 mL
1 mM	2.49 mL	12.44 mL	24.87 mL
5 mM	0.50 mL	2.49 mL	4.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Poland 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 1980 PMID: 7464820
• Tzameli The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 2000 PMID: 10757780
• Ledda-Columbano In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 1998 PMID: 9747883

Product Documents for TCPOBOP