2 agonist and GABAA α
1 partial agonist in vitro
values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo
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Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Primofiore et al.
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) κ2 benzodiazepine receptor.
Taliani et al.