Integrin very late antigen-4 (VLA-4; α4β1
) antagonist (IC50
= 4.4 nM). Blocks the activation of inflammatory cells.
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All Tocris products are intended for laboratory research use only.
Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.
Muro et al.