Catalog Number: 2591
Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
Biological Activity
Potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
Technical Data
  • M.Wt:
    360.43
  • Formula:
    C18H20N2O4S
  • Solubility:
    Soluble to 30 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    301305-73-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
    Patch et al.
    Bioorg.Med.Chem.Lett., 2006;16:3282

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