Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
Biological ActivityPotent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
Patch et al.
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VersaClone cDNA Plasmids
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