Potent inhibitor of FLT3 receptor tyrosine kinase (IC50
= 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50
= 340 nM).
Soluble to 30 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
Patch et al.