Chemical Name: 1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
Biological ActivityOrally active, subtype-selective GluN1A/GluN2B (formally NR1A/NR2B) NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for GluN1A/2B (NR1A/2B), GluN1A/2B (NR1A/2B) and GluN1A/2C (NR1A/2C) receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.
Wright et al.
Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer.
Roger et al.
Citation for TCS 46b
The citations listed below are publications that use Tocris products. Selected citations for TCS 46b include:
1 Citation: Showing 1 - 1
Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
Authors: Carlson Et al.
Brain Behav 2012;2:391
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