TCS JNK 5a

Catalog # Availability Size / Price Qty
2827/10
2827/50
TCS JNK 5a | CAS No. 312917-14-9 | JNK/c-jun Inhibitors
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Description: Selective inhibitor of JNK2 and JNK3

Chemical Name: N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

Purity: ≥99%

Product Details
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Biological Activity

Selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).

Technical Data

M.Wt:
332.42
Formula:
C20H16N2OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
312917-14-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
    Angell et al.
    Bioorg.Med.Chem.Letts., 2007;17:1296

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