TCS PIM-1 1

Tocris Bioscience | Catalog # 2979

Selective, ATP-competitive Pim-1 kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Selective, ATP-competitive Pim-1 kinase inhibitor

Alternative Names

SC 204330
View all Pim Kinase Inhibitors »

Product Description

TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

Product Specifications for TCS PIM-1 1

Molecular Weight

367.20

Formula

C18H11BrN2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

CAS Number

491871-58-0

PubChem ID

1235170

InChI Key

SVSYJTYGPLVUOZ-UHFFFAOYSA-N

SMILES

OC1=C(C2=CC(C3=CC=CC=C3)=C(C#N)C(N2)=O)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.72 100

Preparing Stock Solutions for TCS PIM-1 1

The following data is based on the product molecular weight 367.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.62 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for TCS PIM-1 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCS PIM-1 1

For research use only

Related Research Areas

Epigenetics

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