ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50
values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).
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All Tocris products are intended for laboratory research use only.
Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.
Cheney et al.