TCS PrP Inhibitor 13

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3238/10
3238/50
TCS PrP Inhibitor 13 | CAS No. 34320-83-7 | Neuronal Metabolism Peptides and Compounds
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Description: Antiprion agent; inhibits PrPSc accumulation

Chemical Name: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

Technical Data

M.Wt:
281.27
Formula:
C15H11N3O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
34320-83-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TCS PrP Inhibitor 13

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