TCS PrP Inhibitor 13

Key Product Details

Product Description

TCS PrP Inhibitor 13 is an antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC₅₀ = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

Product Specifications for TCS PrP Inhibitor 13

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCS PrP Inhibitor 13

The following data is based on the product molecular weight 281.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.56 mL	17.78 mL	35.55 mL
5 mM	0.71 mL	3.56 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.56 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

• Provenzano Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017 PMID: 28692055
• Kimata New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 2007 PMID: 17850126

Product Documents for TCS PrP Inhibitor 13