TCS PrP Inhibitor 13

  ( 1 citations )    
Product Datasheet
Catalog Number:3238
Chemical Name:2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Product Details
Citations (1)
Reviews
Biological Activity
Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.
Technical Data
  • M.Wt:
    281.27
  • Formula:
    C15H11N3O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    34320-83-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCS PrP Inhibitor 13 include:

1 Citations: Showing 1 - 1

  1. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours.
    Authors: Provenzano Et al.
    Oncogene.  2017;

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