TEM8/ANTXR1 Antibody Blocking Peptide

Novus Biologicals | Catalog # NBP1-77233PEP

Novus Biologicals
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Key Product Details

Source

Synthetic

Applications

Antibody Competition
View all TEM8/ANTXR1 Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 13 amino acids near the center of human ATR.

Source: Synthetic

(Accession #: NP_444262)

Application Notes

This peptide is useful as a blocking peptide for NBP1-77233.

For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation, and Storage

NBP1-77233PEP
Formulation PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative 0.02% Sodium Azide
Concentration 0.2 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: TEM8/ANTXR1

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Long Name

Tumor Endothelial Marker 8/Anthrax Toxin Receptor 1

Alternate Names

ANTXR1

Gene Symbol

ANTXR1

Additional TEM8/ANTXR1 Products

Product Documents for TEM8/ANTXR1 Antibody Blocking Peptide

Certificate of Analysis

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Product Specific Notices for TEM8/ANTXR1 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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