Tenofovir

Tocris Bioscience | Catalog # 3666

Reverse transcriptase inhibitor
Tocris Bioscience

Key Product Details

Description

Reverse transcriptase inhibitor

Alternative Names

PMPA,(R)-9-(2-Phosphonoylmethoxypropyl)adenine
View all RNA/DNA Polymerase Inhibitors »

Product Description

Tenofovir is a selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.

Product Specifications for Tenofovir

Molecular Weight

287.21

Formula

C9H14N5O4P

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid

CAS Number

147127-20-6

PubChem ID

464205

InChI Key

SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES

C[C@@H](OCP(O)(O)=O)CN(C=N2)C1=C2C(N)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 28.72 100
DMSO 2.87 10

Preparing Stock Solutions for Tenofovir

The following data is based on the product molecular weight 287.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.41 mL 34.82 mL
5 mM 0.70 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for Tenofovir

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tenofovir

For research use only

Related Research Areas

Epigenetics

Customer Reviews for Tenofovir (1)

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  • Study of in vivo tenofovir breakdown
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 12/24/2019
    We studied in vivo tenofovir breakdown.How it is converted to tenofovir. Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.
    Tenofovir 3666

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