Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
Biological ActivityTenofovir is a selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Tsai et al.
9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.
Van Rompay et al.
Antimicrob.Agents Chemother., 1996;40:2586
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine.
Suo et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Tenofovir
Average Rating: 5 (Based on 1 Review)
Have you used Tenofovir?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
We studied in vivo tenofovir breakdown.How it is converted to tenofovir.Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.