Catalog Number: 3666
Alternate Names: PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine
Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
Biological Activity
Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.
Technical Data
  • M.Wt:
    287.21
  • Formula:
    C9H14N5O4P
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    147127-20-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.
    Tsai et al.
    Science, 1995;270:1197
  2. 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.
    Van Rompay et al.
    Antimicrob.Agents Chemother., 1996;40:2586
  3. Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine.
    Suo et al.
    J.Biol.Chem., 1998;273:27250

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