Tenofovir

Catalog # Availability Size / Price Qty
3666/10
3666/50
Tenofovir | CAS No. 147127-20-6 | RNA/DNA Polymerase Inhibitors
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Description: Reverse transcriptase inhibitor
Alternative Names: PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine

Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.

Technical Data

M.Wt:
287.21
Formula:
C9H14N5O4P
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 10 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
147127-20-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Study of in vivo tenofovir breakdown
By Anonymous on 12/24/2019
Application: Species: Mouse

We studied in vivo tenofovir breakdown.How it is converted to tenofovir.Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.


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