Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
Biological ActivitySelectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Tsai et al.
9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.
Van Rompay et al.
Antimicrob.Agents Chemother., 1996;40:2586
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine.
Suo et al.
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We studied in vivo tenofovir breakdown.How it is converted to tenofovir.Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.