Chemical Name: N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
Biological ActivityTenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
Lain et al.
Cancer Cell, 2008;13:454
Citation for Tenovin-1
The citations listed below are publications that use Tocris products. Selected citations for Tenovin-1 include:
1 Citation: Showing 1 - 1
Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses.
Authors: Hackett Et al.
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