p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1
and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro
Soluble to 25 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
Lain et al.
Cancer Cell, 2008;13:454