Tenovin-1

Key Product Details

Product Description

Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21^CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.

Product Specifications for Tenovin-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tenovin-1

The following data is based on the product molecular weight 369.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.83 mL	54.13 mL	108.26 mL
1.25 mM	2.17 mL	10.83 mL	21.65 mL
2.5 mM	1.08 mL	5.41 mL	10.83 mL
12.5 mM	0.22 mL	1.08 mL	2.17 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Lain Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 2008 PMID: 18455128

Product Documents for Tenovin-1