Terazosin hydrochloride

Tocris Bioscience | Catalog # 1506

α1 antagonist; PGK1 activator
Tocris Bioscience

Key Product Details

Description

α1 antagonist; PGK1 activator
View all Adrenergic alpha-1 Receptor Antagonists »

Product Description

Terazosin hydrochloride is a selective α1 antagonist. Increases phosphoglycerate kinase 1 (PGK1) activity (Kd = 2.9 μM). Upregulates glucose metabolism and increases ATP production. In an in vitro model of GI disease, terazosin reduces inflammation and protects against oxidative damage. Neuroprotective in in vivo models of ALS and Parkinson's Disease. Antihypertensive following oral or intravenous administration in vivo.

Product Specifications for Terazosin hydrochloride

Molecular Weight

423.90

Formula

C19H25N5O4.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride

CAS Number

63074-08-8

PubChem ID

44383

InChI Key

IWSWDOUXSCRCKW-UHFFFAOYSA-N

SMILES

Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.48 20 with gentle warming

Preparing Stock Solutions for Terazosin hydrochloride

The following data is based on the product molecular weight 423.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.80 mL 58.98 mL 117.95 mL
1 mM 2.36 mL 11.80 mL 23.59 mL
2 mM 1.18 mL 5.90 mL 11.80 mL
10 mM 0.24 mL 1.18 mL 2.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for Terazosin hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Terazosin hydrochloride

For research use only

Citations for Terazosin hydrochloride

Customer Reviews for Terazosin hydrochloride (1)

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  • Used to investigate cell metabolism
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 12/22/2022
    The drug was incubated at 10 μM to investigate an effect on cell metabolism.

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